Renal physiology and diuretics

Proximal convoluted tubule (PCT)

Working diuretics: osmotic e.g. Mannitol

Reabsorption of:

* Sodium (67%)
* Chloride (40%)
* Potassium (all)
* Water (equiosmotic amount)
* HCO3 ions (85%)
* Glucose, AA (all)

Secretion of:

* Creatinine
* Uric acid
* Antibiotics
* Some diuretics

Henle Loop

Working diuretics: Loop e.g. Furosemide

Reabsorption of:

* Sodium Chloride (25%)
* Potassium [desc. limb only]
* Water (equiosmotic amount) [desc. limb only]
* Magnesium
* Calcium

Secretion of:

* No secretion occurs at this segment

Distal convoluted tubule (DCT)
Working diuretics: thiazides e.g. Chlorothiazide [proximal part] – osmotic e.g. Mannitol, Pottasium sparing e.g. Amiloride [distal part]
Reabsorption of:

* Sodium Chloride (proximal part 10% – distal part 2-5% “under the effect of Aldosterone“)
* Water (equiosmotic amount) [distal part only] “under the effect of Aldosterone“
* Calcium [proximal part only] “under the effect of parathyroid hormone”
* Ammonia [distal part only]

Secretion of: [distal part only]

* Potassium
* Hydrogen

Collecting duct and tubules (medullary part)

Working diuretics: osmotic e.g. Mannitol

Reabsorption of:

* Water “under the effect of Anti-diuretic hormone”

Secretion of:

* No secretion occurs at this segment

VIA